MITOCHONDRIA: Mitochondrial dynamics in the regulation of stem cells

Steven Wade; Mireille Khacho

doi:10.1016/j.biocel.2022.106158

MITOCHONDRIA: Mitochondrial dynamics in the regulation of stem cells

Int J Biochem Cell Biol. 2022 Mar:144:106158. doi: 10.1016/j.biocel.2022.106158. Epub 2022 Jan 19.

Authors

Steven Wade¹, Mireille Khacho²

Affiliations

¹ Department of Biochemistry, Microbiology and Immunology, Ottawa Institute for Systems Biology (OISB) and Center for Neuromuscular Disease (CNMD), Faculty of Medicine, University of Ottawa, Canada.
² Department of Biochemistry, Microbiology and Immunology, Ottawa Institute for Systems Biology (OISB) and Center for Neuromuscular Disease (CNMD), Faculty of Medicine, University of Ottawa, Canada. Electronic address: mkhacho@uottawa.ca.

PMID: 35063637
DOI: 10.1016/j.biocel.2022.106158

Abstract

Mitochondria are considered the metabolic hubs within a cell. These organelles are highly dynamic and continuously undergo cycles of fission and fusion events. The balance in the dynamic state of mitochondria is critical for maintaining key physiological events within cells. Here we discuss the emerging role of mitochondrial dynamics in regulating stem cell function and highlight the crosstalk between mitochondrial shape and intracellular signaling cascades within the context of stem cells.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Mitochondria* / metabolism
Mitochondrial Dynamics*
Organelles / metabolism
Signal Transduction
Stem Cells / metabolism

Grants and funding

CIHR/Canada