Treat People Better.

Revolutionizing Drug Delivery

Rocket Science Health seeks to transform drug delivery to the brain and enable revolutionary treatments through the development of human-centric medical devices.

OUR FOCUS

Targeted Drug Delivery to the Olfactory Region

Enabling New Drugs through Fluidics

Designed for Patient Needs & Physiology

OUR FOCUS

Targeted Drug Delivery to the Olfactory Region

The Opportunity

Current methods of intranasal and systemic drug delivery are missing the target.
Only a fraction of the dose volume reaches the olfactory region in currently marketed nasal spray devices.
- Warnken et al, Mol. Pharmace utics, Xi et al, Pharm. Res, Cooper & Gavatash, Drug Delivery to the Lungs
Brain disorders affect up to 1 billion people worldwide.
- Neurological Disorders: Public Health Challenges, WHO

Neurological disorders are the leading cause of disability and the second leading cause of death worldwide. - Feigin et al, Lancet Neurology
Drug development for brain disorders is difficult.
Many obstacles inhibit drugs from reaching sites-of-action in the brain, resulting in poor brain exposure. About 95% of small molecule and nearly all large molecule drug therapies approved by the FDA cannot enter the central nervous system from systemic circulation.
- Pardridge et al, NeuroRX
Current methods of intranasal and systemic drug delivery are missing the target.
Only a fraction of the dose volume reaches the olfactory region in currently marketed nasal spray devices.
- Warnken et al, Mol. Pharmace utics, Xi et al, Pharm. Res, Cooper & Gavatash, Drug Delivery to the Lungs
Brain disorders affect up to 1 billion people worldwide.
- Neurological Disorders: Public Health Challenges, WHO

Neurological disorders are the leading cause of disability and the second leading cause of death worldwide. - Feigin et al, Lancet Neurology

The Solution

Targeting the Olfactory Cleft

A Promising Pathway

The upper nasal cavity offers a unique access point that can enhance the brain's exposure to drug therapies. RSH is developing a proprietary intranasal device that enables accurate liquid drug delivery to this important region.

OLFACTORY

CLEFT

OLFACTORY

CLEFT

NERVOUS SYSTEMCNS VASCULATURESYSTEMIC VASCULATURE

NERVOUSSYSTEMCNSVASCULATURESYSTEMICVASCULATURE

RSH SOLUTION

Enabling New Drugs

Leveraging Fluidics

Nasal spray particles can be impeded by the circuitous nasal anatomy, requiring propellent or other techniques to marginally improve deposition high in the nasal cavity. Our testing demonstrates that our ejected fluid profile can repeatedly navigate these tight channels, allowing a drug formulation to reach the target deposition site in the olfactory region while avoiding formulation degradation often caused by high-force sprays and other intranasal devices currently available on the market.

NASAL SPRAY¹

RSH LAMINAR FLOW

¹Djupesland, P.G. Nasal drug delivery devices: characteristics and performance in a clinical perspective—a review. Drug Deliv. and Transl. Res.

RSH SOLUTION

Importance of Designing for Humans

Inclusive Human Factors

Every patient is different and has unique factors that affect their ability to use existing hand-held nasal spray devices. RSH prioritizes inclusive human factors design as key to consumer adoption, adherence, and ensuring the dose gets to the target region, every time. The device we are developing is intended to be the first self-guided and anatomical aligning device that is intuitive for all to use.

RSH SOLUTION

Importance of Designing for Humans

Inclusive Human Factors

RSH RESEARCH

Backed by Research

Investigative Studies

Rocket Science Health is conducting extensive testing to create a compelling evidence-base for targeted olfactory delivery with our proprietary technology, from the bench to the clinic. RSH has demonstrated:

Ejection Geometry Studies
A unique ejection geometry that enables repeatable olfactory delivery in nasal casts.
In-Human Deposition Studies
Targeted olfactory deposition in multiple human studies using RSH device.
In-Human Physiological Studies
Our proprietary guided technology in multiple human CR studies.
HFUE Formative Studies
Formative human factors evaluations that showcase favourable usability and repeatable insertion of RSH form factor.
Consumer Insight Studies
Consumer insight research highlights lessened anxiety around RSH’s form factor compared with other intranasal devices.

ADDITIONAL INITIATIVES

Holistic Approach to Drug Therapies

Rocket Science Health embraces a holistic approach to drug therapies that integrate cutting-edge drug delivery technology, software and biomarker sampling aimed at improving patient well-being and overall treatment success.

Biomarker Diagnostics

Proof Positive Software

Extended Applications

Biomarker Diagnostics

ABOUT US

It’s Not Rocket Science.

Rocket Science Health seeks to enable revolutionary patient treatments by exploiting the intranasal direct-to-brain pathway through development of human-centric medical devices, advanced biomarker sampling, and proof positive drug delivery software.

The collective passion, drive for innovation, and functional expertise of our team are palpable, continuously striving to push boundaries and develop cutting-edge superior product. Together, we seek to pave the way for groundbreaking advancements in our field and make a lasting impact on the industry and society.

Leadership

Science Advisors

Treat People Better.

Targeted Drug Delivery to the Olfactory Region

Enabling New Drugs through Fluidics

Designed for Patient Needs & Physiology

Targeted Drug Delivery to the Olfactory Region

Targeting the Olfactory Cleft

A Promising Pathway

Enabling New Drugs

Leveraging Fluidics

Importance of Designing for Humans

Inclusive Human Factors

Importance of Designing for Humans

Inclusive Human Factors

Backed by Research

Investigative Studies

Ejection Geometry Studies

In-Human Deposition Studies

In-Human Physiological Studies

HFUE Formative Studies

Consumer Insight Studies

Holistic Approach to Drug Therapies

Biomarker Diagnostics

Proof Positive Software

Extended Applications

Biomarker Diagnostics

It’s Not Rocket Science.

Leadership

Science Advisors

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