Neuron
Volume 101, Issue 5, 6 March 2019, Pages 774-778
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Ketamine: A Paradigm Shift for Depression Research and Treatment

https://doi.org/10.1016/j.neuron.2019.02.005Get rights and content
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Ketamine is the first exemplar of a rapid-acting antidepressant with efficacy for treatment-resistant symptoms of mood disorders. Its discovery emerged from a reconceptualization of the biology of depression. Neurobiological insights into ketamine efficacy shed new light on the mechanisms underlying antidepressant efficacy.

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